Here an example of a Quick game.
Menu -> Sets
In this case the opponent is Moses!
The human player in this game mode is "stateless", this is a quick game where the player just choses one of the available decks. And choses a (named) AI to battle. If the AI allows it, you can further change the deck the AI will use.
Optional
You can chose to select "Gen Deck" - which will generate a random deck for the selected player.
Random deck generation is based on diverse settings (how to change those - look below) select an appropiate setting - and...
Press "Start game" and the game begins!